The JWH molecules have been 1st synthesized by John William Huffman at Clemson University during the late 1990s.[eighty three] The FBI concluded inside of a 2012 memo that on account of the publication of J.W. Huffman's research, folks hunting for a "marijuana-like-high" would observe his recipes and methods.[five]
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Most artificial cannabinoids are agonists on the cannabinoid receptors. They are already designed to be similar to THC,[9] the organic cannabinoid Along with the strongest binding affinity to your CB1 receptor, and that is associated with the psychoactive outcomes or "high" of cannabis.[ten] These synthetic analogs generally have increased binding affinity and better potency to your CB1 receptors.
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